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| 09.04.2022 | 14:00 | Bayburt İl Özel İdare | - | Niğde Anadolu FK | 4:3 (2:1) | |
| 14:00 | Etimesgut Belediyespor | - | Sakaryaspor | 0:0 (0:0) | ||
| 14:00 | Kahramanmaraşspor | - | Afjet Afyonspor | 0:1 (0:0) | ||
| 14:00 | Vanspor FK | - | Somaspor | 1:0 (1:0) | ||
| 10.04.2022 | 13:00 | Serik Belediyespor | - | Diyarbekirspor | 2:0 (2:0) | |
| 14:00 | Bodrumspor | - | Ankaraspor | 2:0 (0:0) | ||
| 14:00 | Çorum FK | - | 1461 Trabzon FK | 2:1 (0:0) | ||
| 14:00 | Sarıyer SK | - | Inegölspor | 5:1 (1:0) | ||
| 14:00 | Sivas Belediyespor | - | Adıyamanspor | 5:0 (2:0) | ||
| 14:00 | Turgutluspor | - | Ergene Velimeşe | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 34 | 22 | 9 | 3 | 69:22 | 47 | 75 |
| 2 |
|
Bodrumspor | 34 | 20 | 7 | 7 | 56:24 | 32 | 67 |
| 3 |
|
1461 Trabzon FK | 34 | 20 | 7 | 7 | 59:28 | 31 | 67 |
| 4 |
|
Sivas Belediyespor | 34 | 17 | 9 | 8 | 62:32 | 30 | 60 |
| 5 |
|
Afjet Afyonspor | 34 | 17 | 8 | 9 | 61:35 | 26 | 59 |
| 6 |
|
Vanspor FK | 34 | 16 | 11 | 7 | 46:39 | 7 | 59 |
| 7 |
|
Çorum FK | 34 | 16 | 10 | 8 | 49:31 | 18 | 58 |
| 8 |
|
Bayburt İl Özel İdare | 34 | 16 | 8 | 10 | 44:34 | 10 | 56 |
| 9 |
|
Somaspor | 34 | 15 | 7 | 12 | 48:44 | 4 | 52 |
| 10 |
|
Inegölspor | 34 | 14 | 7 | 13 | 48:49 | -1 | 49 |
| 11 |
|
Ankaraspor | 34 | 12 | 11 | 11 | 48:38 | 10 | 47 |
| 12 |
|
Etimesgut Belediyespor | 34 | 10 | 11 | 13 | 39:49 | -10 | 41 |
| 13 |
|
Sarıyer SK | 34 | 10 | 9 | 15 | 43:50 | -7 | 39 |
| 14 |
|
Serik Belediyespor | 34 | 11 | 6 | 17 | 41:49 | -8 | 39 |
| 15 |
|
Diyarbekirspor | 34 | 11 | 5 | 18 | 30:40 | -10 | 38 |
| 16 |
|
Adıyamanspor | 34 | 11 | 2 | 21 | 40:65 | -25 | 35 |
| 17 |
|
Turgutluspor | 34 | 8 | 10 | 16 | 28:53 | -25 | 34 |
| 18 |
|
Ergene Velimeşe | 34 | 8 | 4 | 22 | 32:68 | -36 | 28 |
| 19 |
|
Niğde Anadolu FK | 34 | 5 | 7 | 22 | 35:77 | -42 | 22 |
| 20 |
|
Kahramanmaraşspor | 34 | 4 | 6 | 24 | 22:73 | -51 | 18 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
