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| 22.04.2022 | 19:30 | Çaykur Rizespor | - | Fenerbahçe | 0:6 (0:3) | |
| 23.04.2022 | 15:00 | Gaziantep FK | - | Göztepe | 1:1 (0:0) | |
| 15:00 | Fatih Karagümrük SK | - | Giresunspor | 2:1 (0:0) | ||
| 19:30 | Adana Demirspor | - | Trabzonspor | 1:3 (0:2) | ||
| 24.04.2022 | 15:00 | İstanbul Başakşehir | - | Hatayspor | 3:0 (0:0) | |
| 15:00 | Yeni Malatyaspor | - | Konyaspor | 2:3 (0:2) | ||
| 19:30 | Altay Izmir | - | Galatasaray | 0:1 (0:1) | ||
| 19:30 | Antalyaspor | - | Kayserispor | 1:1 (0:0) | ||
| 25.04.2022 | 19:30 | Beşiktaş | - | Kasımpaşa SK | 0:3 (0:2) | |
| 19:30 | Sivasspor | - | Alanyaspor | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 34 | 22 | 10 | 2 | 63:29 | 34 | 76 |
| 2 |
|
Fenerbahçe | 34 | 19 | 8 | 7 | 64:35 | 29 | 65 |
| 3 |
|
Konyaspor | 34 | 19 | 7 | 8 | 59:38 | 21 | 64 |
| 4 |
|
İstanbul Başakşehir | 34 | 17 | 6 | 11 | 49:32 | 17 | 57 |
| 5 |
|
Adana Demirspor | 34 | 14 | 10 | 10 | 50:40 | 10 | 52 |
| 6 |
|
Alanyaspor | 34 | 15 | 7 | 12 | 59:56 | 3 | 52 |
| 7 |
|
Beşiktaş | 34 | 13 | 12 | 9 | 49:44 | 5 | 51 |
| 8 |
|
Antalyaspor | 34 | 14 | 9 | 11 | 44:40 | 4 | 51 |
| 9 |
|
Fatih Karagümrük SK | 34 | 14 | 8 | 12 | 42:49 | -7 | 50 |
| 10 |
|
Hatayspor | 34 | 14 | 7 | 13 | 50:54 | -4 | 49 |
| 11 |
|
Kasımpaşa SK | 34 | 13 | 8 | 13 | 56:47 | 9 | 47 |
| 12 |
|
Galatasaray | 34 | 13 | 8 | 13 | 45:47 | -2 | 47 |
| 13 |
|
Sivasspor | 34 | 11 | 12 | 11 | 44:43 | 1 | 45 |
| 14 |
|
Kayserispor | 34 | 11 | 10 | 13 | 47:55 | -8 | 43 |
| 15 |
|
Gaziantep FK | 34 | 11 | 9 | 14 | 43:49 | -6 | 42 |
| 16 |
|
Giresunspor | 34 | 11 | 7 | 16 | 36:41 | -5 | 40 |
| 17 |
|
Altay Izmir | 34 | 8 | 6 | 20 | 34:50 | -16 | 30 |
| 18 |
|
Çaykur Rizespor | 34 | 8 | 6 | 20 | 33:65 | -32 | 30 |
| 19 |
|
Göztepe | 34 | 7 | 7 | 20 | 38:58 | -20 | 28 |
| 20 |
|
Yeni Malatyaspor | 34 | 5 | 5 | 24 | 25:58 | -33 | 20 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
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# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
