 |
 |
|
|
| 24.09.2021 | 18:30 | Kolos Kovalivka | - | Vorskla Poltava | 0:1 (0:1) | |
| 25.09.2021 | 13:00 | FK Oleksandriya | - | FK Mariupol | 2:1 (1:1) | |
| 16:00 | Shakhtar Donetsk | - | NK Veres | 4:1 (1:1) | ||
| 18:30 | Rukh Lviv | - | Dinamo Kiev | 0:2 (0:2) | ||
| 26.09.2021 | 13:00 | FC Mynai | - | FK Lviv | 1:2 (1:1) | |
| 16:00 | SK Dnipro-1 | - | Zorya Lugansk | 0:4 (0:1) | ||
| 18:30 | Desna Chernigov | - | Metalist 1925 Kharkiv | 1:2 (1:1) | ||
| 27.09.2021 | 18:30 | Chernomorets Odessa | - | Inhulets Petrove | 1:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 9 | 8 | 1 | 0 | 25:2 | 23 | 25 |
| 2 |
|
Shakhtar Donetsk | 9 | 7 | 1 | 1 | 23:5 | 18 | 22 |
| 3 |
|
Vorskla Poltava | 9 | 5 | 3 | 1 | 16:7 | 9 | 18 |
| 4 |
|
Zorya Lugansk | 9 | 5 | 2 | 2 | 20:9 | 11 | 17 |
| 5 |
|
FK Oleksandriya | 9 | 5 | 2 | 2 | 10:7 | 3 | 17 |
| 6 |
|
SK Dnipro-1 | 9 | 5 | 1 | 3 | 13:12 | 1 | 16 |
| 7 |
|
Desna Chernigov | 9 | 5 | 1 | 3 | 13:14 | -1 | 16 |
| 8 |
|
NK Veres | 9 | 3 | 2 | 4 | 9:12 | -3 | 11 |
| 9 |
|
Metalist 1925 Kharkiv | 9 | 3 | 1 | 5 | 8:13 | -5 | 10 |
| 10 |
|
Kolos Kovalivka | 9 | 2 | 3 | 4 | 6:14 | -8 | 9 |
| 11 |
|
Inhulets Petrove | 9 | 2 | 2 | 5 | 9:15 | -6 | 8 |
| 12 |
|
Rukh Lviv | 9 | 2 | 2 | 5 | 6:12 | -6 | 8 |
| 13 |
|
FC Mynai | 9 | 1 | 4 | 4 | 7:12 | -5 | 7 |
| 14 |
|
FK Lviv | 9 | 1 | 3 | 5 | 6:14 | -8 | 6 |
| 15 |
|
Chernomorets Odessa | 9 | 1 | 3 | 5 | 10:22 | -12 | 6 |
| 16 |
|
FK Mariupol | 9 | 1 | 1 | 7 | 12:23 | -11 | 4 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
|
# Olimpik Donetsk zog sich vor Beginn der Saison aus allen Wettbewerben zurück. Der Verein wurde aufgelöst. |
