 |
 |
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| H | CA Cerro | - | Defensor Sporting | 1:2 (1:1) | ||
| R | Defensor Sporting | - | CA Cerro | 0:1 (0:0) | ||
| H: 30.11.2021 23:00 | R: 04.12.2021 01:45 | Sieger: Defensor Sporting | ||||
| H | Central Español | - | Racing | 0:0 (0:0) | ||
| R | Racing | - | Central Español | 1:1 (0:1) | ||
| H: 01.12.2021 01:45 | R: 03.12.2021 23:00 | Sieger: Central Español | ||||
