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| 14.09.2021 | 13:15 | FK Qo’qon 1912 | - | FK Mash'al Mubarek | 2:2 (2:1) | |
| 15.09.2021 | 13:15 | Andijon PFK | - | Metallurg Bekobod | 1:2 (0:0) | |
| 16:00 | FC AGMK | - | FK Turon | 2:0 (0:0) | ||
| 16:00 | Pakhtakor Tashkent | - | Navbahor Namangan | 0:0 (0:0) | ||
| 16.09.2021 | 16:00 | Lokomotiv Tashkent | - | Surkhon Termez FK | 2:0 (0:0) | |
| 16:00 | FC Nasaf | - | Qizilqum Zarafshon | 2:1 (2:0) | ||
| 16:00 | So’g’diyona PFK | - | Bunyodkor PFK | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pakhtakor Tashkent | 18 | 15 | 3 | 0 | 32:6 | 26 | 48 |
| 2 |
|
So’g’diyona PFK | 18 | 9 | 7 | 2 | 22:12 | 10 | 34 |
| 3 |
|
FC AGMK | 18 | 9 | 5 | 4 | 23:17 | 6 | 32 |
| 4 |
|
FC Nasaf | 18 | 9 | 3 | 6 | 27:16 | 11 | 30 |
| 5 |
|
Bunyodkor PFK | 18 | 8 | 5 | 5 | 28:16 | 12 | 29 |
| 6 |
|
Lokomotiv Tashkent | 18 | 7 | 5 | 6 | 24:19 | 5 | 26 |
| 7 |
|
Qizilqum Zarafshon | 18 | 6 | 8 | 4 | 20:17 | 3 | 26 |
| 8 |
|
Navbahor Namangan | 18 | 6 | 7 | 5 | 15:13 | 2 | 25 |
| 9 |
|
FK Qo’qon 1912 | 18 | 5 | 6 | 7 | 22:24 | -2 | 21 |
| 10 |
|
Metallurg Bekobod | 18 | 6 | 1 | 11 | 17:26 | -9 | 19 |
| 11 |
|
FK Mash'al Mubarek | 18 | 4 | 5 | 9 | 16:27 | -11 | 17 |
| 12 |
|
Surkhon Termez FK | 18 | 4 | 2 | 12 | 10:31 | -21 | 14 |
| 13 |
|
FK Turon | 18 | 2 | 6 | 10 | 11:26 | -15 | 12 |
| 14 |
|
Andijon PFK | 18 | 3 | 3 | 12 | 14:31 | -17 | 12 |
| Champions League | |
| Champions League Quali. | |
| Relegation | |
| Abstieg |
