| 1. Runde | 11.03.2021 | Real Santander | - | Cortuluá | 1:1 |  |
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| 1. Runde | 18.03.2021 | Cortuluá | - | Real Santander | 1:2 | ||||
| 2. Runde | 15.04.2021 | Leones FC | - | Real Santander | 1:3 | ||||
| 2. Runde | 21.04.2021 | Real Santander | - | Leones FC | 2:0 | ||||
| 3. Runde | 28.07.2021 | Patriotas FC | - | Real Santander | 1:0 | ||||
| 3. Runde | 04.08.2021 | Real Santander | - | Patriotas FC | 4:5 i.E. |
Kolumbien