| Zona B | 21.02.2021 | Sacachispas | - | Achuapa | 1:0 |  |
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| Zona B | 28.02.2021 | Sanarate | - | Sacachispas | 0:0 | ||||
| Zona B | 03.03.2021 | Cobán Imperial | - | Sacachispas | 2:2 |  |
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| Zona B | 07.03.2021 | Sacachispas | - | Deportivo Guastatoya | 0:1 | ||||
| Zona B | 10.03.2021 | CSD Municipal | - | Sacachispas | 1:2 | |
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| Zona B | 13.03.2021 | Achuapa | - | Sacachispas | 2:1 | |
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| Zona B | 01.04.2021 | Sacachispas | - | Sanarate | 2:1 | |
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| Zona B | 04.04.2021 | Sacachispas | - | Cobán Imperial | 1:2 | |
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| Zona B | 11.04.2021 | Sacachispas | - | CSD Municipal | 0:3 | ||||
| Interzone | 15.04.2021 | Sacachispas | - | Comunicaciones | 1:0 | |
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| Interzone | 17.04.2021 | Iztapa | - | Sacachispas | 4:0 | ||||
| Interzone | 22.04.2021 | Sacachispas | - | Santa Lucía | 1:2 | |
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| Interzone | 25.04.2021 | Xelaju MC | - | Sacachispas | 3:1 | |
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| Interzone | 29.04.2021 | Sacachispas | - | Deportivo Malacateco | 2:1 | |
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| Interzone | 02.05.2021 | Antigua GFC | - | Sacachispas | 1:1 | ||||
| Viertelfinale | 06.05.2021 | Sacachispas | - | Comunicaciones | 0:1 | ||||
| Viertelfinale | 09.05.2021 | Comunicaciones | - | Sacachispas | 1:0 |
Ecuador