| Zona B | 27.02.2021 | CSD Municipal | - | Deportivo Guastatoya | 0:1 | ||||
| Zona B | 03.03.2021 | CSD Municipal | - | Sanarate | 3:1 |  |
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| Zona B | 07.03.2021 | Achuapa | - | CSD Municipal | 1:2 | ||||
| Zona B | 10.03.2021 | CSD Municipal | - | Sacachispas | 1:2 | |
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| Zona B | 13.03.2021 | CSD Municipal | - | Cobán Imperial | 2:0 | ||||
| Zona B | 01.04.2021 | Deportivo Guastatoya | - | CSD Municipal | 0:0 | ||||
| Zona B | 04.04.2021 | Sanarate | - | CSD Municipal | 2:1 | ||||
| Zona B | 07.04.2021 | CSD Municipal | - | Achuapa | 3:0 | |
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| Zona B | 11.04.2021 | Sacachispas | - | CSD Municipal | 0:3 | |
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| Interzone | 14.04.2021 | CSD Municipal | - | Deportivo Malacateco | 3:0 | |
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| Interzone | 28.04.2021 | CSD Municipal | - | Santa Lucía | 2:1 | |
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| Interzone | 02.05.2021 | Xelaju MC | - | CSD Municipal | 0:3 | |
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