| Zona B | 28.02.2021 | Achuapa | - | Cobán Imperial | 2:1 | ||||
| Interzone | 18.04.2021 | Deportivo Malacateco | - | Achuapa | 1:0 | ||||
| Interzone | 21.04.2021 | Achuapa | - | Antigua GFC | 1:2 | ||||
| Interzone | 26.04.2021 | Comunicaciones | - | Achuapa | 2:1 | ||||
| Interzone | 28.04.2021 | Achuapa | - | Iztapa | 0:3 | ||||
| Interzone | 02.05.2021 | Santa Lucía | - | Achuapa | 0:2 |
Guatemala