| 1. Spieltag | 05.02.2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
| 2. Spieltag | 11.02.2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 3. Spieltag | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
| 5. Spieltag | 07.03.2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 6. Spieltag | 11.03.2022 | Sportivo Ameliano | - | Tacuary | 0:2 | ||||
| 7. Spieltag | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 |  |
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| 8. Spieltag | 04.04.2022 | Guaraní | - | Tacuary | 1:2 | ||||
| 9. Spieltag | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
| 10. Spieltag | 19.04.2022 | Sol de América | - | Tacuary | 1:0 | ||||
| 11. Spieltag | 22.04.2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
| 14. Spieltag | 07.05.2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 16. Spieltag | 16.05.2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 17. Spieltag | 20.05.2022 | Tacuary | - | Sportivo Ameliano | 1:0 |
Guatemala