| 1. Spieltag | 11.09.2021 | KF Tiranë | - | KF Skënderbeu | 4:2 |  |
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| 2. Spieltag | 19.09.2021 | KF Tiranë | - | Egnatia Rrogozhine | 1:1 | |
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| 3. Spieltag | 25.09.2021 | KS Kastrioti | - | KF Tiranë | 1:1 | |
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| 4. Spieltag | 03.10.2021 | KF Tiranë | - | KF Laçi | 2:0 | ||||
| 5. Spieltag | 17.10.2021 | KF Teuta Durrës | - | KF Tiranë | 2:3 | ||||
| 6. Spieltag | 25.10.2021 | KF Tiranë | - | FK Partizani | 1:0 | ||||
| 7. Spieltag | 30.10.2021 | FK Vllaznia | - | KF Tiranë | 0:2 | |
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| 9. Spieltag | 22.11.2021 | FK Kukësi | - | KF Tiranë | 2:1 | ||||
| 10. Spieltag | 27.11.2021 | KF Skënderbeu | - | KF Tiranë | 0:0 | ||||
| 11. Spieltag | 04.12.2021 | Egnatia Rrogozhine | - | KF Tiranë | 0:2 | |
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| 12. Spieltag | 07.12.2021 | KF Tiranë | - | KS Kastrioti | 3:0 | |
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| 13. Spieltag | 14.12.2021 | KF Laçi | - | KF Tiranë | 1:0 | |
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| 14. Spieltag | 19.12.2021 | KF Tiranë | - | KF Teuta Durrës | 2:1 | ||||
| 15. Spieltag | 23.12.2021 | FK Partizani | - | KF Tiranë | 1:2 | |
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