| Zona B | 21.02.2021 | Sacachispas | - | Achuapa | 1:0 | ||||
| Zona B | 28.02.2021 | Achuapa | - | Cobán Imperial | 2:1 | ||||
| Zona B | 03.03.2021 | Deportivo Guastatoya | - | Achuapa | 3:0 | ||||
| Zona B | 07.03.2021 | Achuapa | - | CSD Municipal | 1:2 | ||||
| Zona B | 10.03.2021 | Sanarate | - | Achuapa | 2:1 |  |
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| Zona B | 13.03.2021 | Achuapa | - | Sacachispas | 2:1 | |
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| Zona B | 31.03.2021 | Cobán Imperial | - | Achuapa | 3:2 | |
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| Zona B | 04.04.2021 | Achuapa | - | Deportivo Guastatoya | 1:0 | ||||
| Zona B | 07.04.2021 | CSD Municipal | - | Achuapa | 3:0 | ||||
| Zona B | 11.04.2021 | Achuapa | - | Sanarate | 2:2 | |
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| Interzone | 14.04.2021 | Achuapa | - | Xelaju MC | 1:1 | ||||
| Interzone | 18.04.2021 | Deportivo Malacateco | - | Achuapa | 1:0 | ||||
| Interzone | 21.04.2021 | Achuapa | - | Antigua GFC | 1:2 | ||||
| Interzone | 26.04.2021 | Comunicaciones | - | Achuapa | 2:1 | |
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| Interzone | 28.04.2021 | Achuapa | - | Iztapa | 0:3 | ||||
| Interzone | 02.05.2021 | Santa Lucía | - | Achuapa | 0:2 | |
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