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| 07.01.2022 | 20:45 | Glenavon FC | - | Crusaders FC | 0:4 | |
| 08.01.2022 | 14:30 | Knockbreda FC | - | Dungannon Swifts | 0:2 | |
| 14:30 | Queen's University Belfast | - | Newington Youth Club | 2:0 | ||
| 16:00 | Dundela FC | - | Ards FC | 3:2 | ||
| 16:00 | Ballinamallard United FC | - | Ards Rangers FC | 2:0 n.V. | ||
| 16:00 | Ballyclare Comrades | - | Carrick Rangers | 0:2 | ||
| 16:00 | Ballymena United | - | Loughgall FC | 2:0 | ||
| 16:00 | Bangor FC | - | Larne FC | 0:5 | ||
| 16:00 | Cliftonville FC | - | Islandmagee FC | 5:0 | ||
| 16:00 | Coleraine FC | - | Windmill Stars | 6:0 | ||
| 16:00 | Dergview FC | - | Glentoran FC | 2:3 | ||
| 16:00 | H&W Welders | - | Annagh United | 1:2 | ||
| 16:00 | Institute FC Drumahoe | - | Portstewart FC | 0:1 | ||
| 16:00 | Linfield FC | - | Oxford Sunnyside | 4:0 | ||
| 16:00 | Portadown FC | - | Limavady United | 2:0 | ||
| 16:00 | Warrenpoint Town | - | Newry City FC | 1:2 |
