| Qual. 2. Runde | 17.10.2021 | AS Maniema Union | - | Mamelodi Sundowns | 2:2 | ||||
| Qual. 2. Runde | 24.10.2021 | Mamelodi Sundowns | - | AS Maniema Union | 2:0 | ||||
| Gruppe A | 11.02.2022 | Mamelodi Sundowns | - | Al Hilal Omdurman | 1:0 | ||||
| Gruppe A | 19.02.2022 | Al Merrikh SC | - | Mamelodi Sundowns | 0:0 | ||||
| Gruppe A | 26.02.2022 | Al Ahly SC | - | Mamelodi Sundowns | 0:1 |  |
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| Gruppe A | 12.03.2022 | Mamelodi Sundowns | - | Al Ahly SC | 1:0 | ||||
| Viertelfinale | 16.04.2022 | Petro Atlético | - | Mamelodi Sundowns | 2:1 |
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