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| 28.09.2021 | 16:00 | Gradina Srebrenik | - | FK Tuzla City | 2:5 | |
| 16:00 | NK Travnik | - | HŠK Posušje | 1:2 | ||
| 29.09.2021 | 16:00 | HNK Čapljina | - | Radnik Bijeljina | 1:2 | |
| 16:00 | FK Klis | - | Igman Konjic | 0:1 | ||
| 16:00 | Rudar Han Bila | - | Željezničar Sarajevo | 0:6 | ||
| 16:00 | Ljubić Prnjavor | - | NK GOŠK Gabela | 1:0 | ||
| 16:00 | FK Goražde | - | Sloboda Tuzla | 0:2 | ||
| 16:00 | FK Modriča | - | FK Sarajevo | 1:4 | ||
| 16:00 | Svatovac Poljice | - | Zrinjski Mostar | 1:2 | ||
| 16:00 | Stupčanica Olovo | - | Borac Banja Luka | 1:3 | ||
| 16:00 | FK Omarska | - | FK Rudar | 5:4 i.E. | ||
| 16:00 | HNK Sloga | - | Željezničar Banja Luka | 1:0 | ||
| 16:00 | Sloboda Mrkonjić | - | Široki Brijeg | 0:1 | ||
| 06.10.2021 | 15:00 | Sloboda Novi Grad | - | Leotar Trebinje | 1:2 (0:0) | |
| 15:00 | Zvijezda 09 Bijeljina | - | Velež Mostar | 0:3 (0:1) | ||
| 15:00 | FK Krupa | - | Zvijezda Gradačac | 0:2 (0:1) |
