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| 07.03.2023 | 23:00 | Audax Italiano | - | Universidad Católica | 3:2 (1:2) | |
| 23:00 | Tacuary | - | General Caballero DJLM | 4:2 (1:0, 2:2) i.E. | ||
| 08.03.2023 | 01:00 | River Plate | - | Peñarol | 0:4 (0:3) | |
| 01:00 | Caracas FC | - | Academia Puerto Cabello | 0:1 (0:0) | ||
| 03:00 | LDU Quito | - | Delfín SC | 4:0 (2:0) | ||
| 23:00 | CD Guabirá | - | Oriente Petrolero | 0:1 (0:0) | ||
| 23:00 | Guaraní | - | Sportivo Ameliano | 3:1 (1:0) | ||
| 23:00 | Defensor Sporting | - | Danubio | 3:4 (0:0, 0:0) i.E. | ||
| 09.03.2023 | 01:00 | Águilas Doradas | - | Santa Fe | 1:2 (0:1) | |
| 01:00 | Estudiantes de Mérida | - | Deportivo Táchira | 3:1 (0:1, 1:1) i.E. | ||
| 03:00 | Universidad Cesar Vallejo | - | Deportivo Binacional | 3:1 (1:1) | ||
| 23:00 | Blooming | - | Atlético Palmaflor | 6:0 (3:0) | ||
| 23:00 | Cobresal | - | Palestino | 0:1 (0:1) | ||
| 10.03.2023 | 01:00 | Deportes Tolima | - | Atlético Junior | 1:0 (1:0) | |
| 01:00 | Emelec | - | Deportivo Cuenca | 2:1 (1:0) | ||
| 03:00 | Universitario de Deportes | - | Cienciano | 2:0 (1:0) |
