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| 05.03.2025 | 01:30 | Universitario de Vinto | - | Nacional Potosí | 0:1 (0:1) | |
| 01:30 | Universidad Católica | - | Palestino | 4:5 (0:1, 1:1) i.E. | ||
| 01:30 | Sportivo Luqueño | - | Sportivo Ameliano | 2:0 (0:0) | ||
| 03:00 | AD Tarma | - | Cienciano | 5:6 (0:0, 1:1) i.E. | ||
| 23:00 | Club Aurora | - | GV San José | 0:1 (0:0) | ||
| 23:00 | Unión Española | - | Everton | 3:1 (2:1, 2:2) i.E. | ||
| 23:00 | Racing | - | Montevideo Wanderers | 4:2 (0:0, 0:0) i.E. | ||
| 23:00 | Academia Puerto Cabello | - | Metropolitanos FC | 3:0 (0:0) | ||
| 06.03.2025 | 01:30 | Once Caldas | - | Millonarios | 1:0 (0:0) | |
| 03:00 | Mushuc Runa | - | Orense SC | 2:1 (1:1) | ||
| 23:00 | Guaraní | - | 2 de Mayo | 2:0 (1:0) | ||
| 23:00 | Cerro Largo | - | Danubio | 4:3 (2:0, 2:2) i.E. | ||
| 07.03.2025 | 01:30 | Atlético Junior | - | América de Cali | 3:4 (0:2, 2:2) i.E. | |
| 01:30 | Atlético Grau | - | Cusco FC | 4:2 (0:0, 0:0) i.E. | ||
| 01:30 | Deportivo La Guaira | - | Caracas FC | 0:2 (0:1) | ||
| 03:00 | Universidad Catolica | - | Aucas | 4:2 (0:0, 0:0) i.E. |
