5. Runde
21.09.2021 14:00 Şomuz Fălticeni Şomuz Fălticeni - FC Voluntari FC Voluntari 1:4
21.09.2021 15:00 Minaur Baia Mare Minaur Baia Mare - CSMS Iasi CSMS Iasi 3:1
21.09.2021 17:45 Petrolul Ploieşti Petrolul Ploieşti - FC Universitatea Craiova FC Universitatea Craiova 0:1
21.09.2021 20:30 CS Mioveni CS Mioveni - Rapid Bucureşti Rapid Bucureşti 4:5 i.E.
22.09.2021 14:00 Argeș Pitești Argeș Pitești - FC Botoşani FC Botoşani 4:2 i.E.
22.09.2021 15:30 CSS Slatina CSS Slatina - FC Dunărea Călărași FC Dunărea Călărași 1:2
22.09.2021 15:30 FK Csikszereda FK Csikszereda - Chindia Târgoviște Chindia Târgoviște 0:1
22.09.2021 15:30 Unirea Slobozia Unirea Slobozia - ASU Poli Timişoara ASU Poli Timişoara 0:1
22.09.2021 15:30 Concordia Chiajna Concordia Chiajna - Gaz Metan Mediaş Gaz Metan Mediaş 0:1 n.V.
22.09.2021 15:30 Gloria Buzau Gloria Buzau - Academica Clinceni Academica Clinceni 2:1 n.V.
22.09.2021 15:30 ASC Oradea ASC Oradea - FC Hermannstadt FC Hermannstadt 0:1
22.09.2021 17:00 Farul Constanta Farul Constanta - Sepsi OSK Sepsi OSK 0:1
22.09.2021 20:00 FC Hunedoara FC Hunedoara - FCSB FCSB 3:5 n.V.
23.09.2021 15:00 Filiaşi Filiaşi - UTA Arad UTA Arad 1:0
23.09.2021 17:45 Ripensia Timisoara Ripensia Timisoara - Dinamo Bucureşti Dinamo Bucureşti 0:1
23.09.2021 20:30 CS Universitatea Craiova CS Universitatea Craiova - CFR Cluj CFR Cluj 1:0