 |
 |
| Viertelfinale | ||||||
|---|---|---|---|---|---|---|
| 03.12.2021 | 19:45 | Cruz Azul | - | UANL Tigres | 0:4 (0:3) | |
| 04.12.2021 | 01:00 | Santos Laguna | - | Atlas Guadalajara | 2:2 (0:0) | |
| 03:00 | CF América | - | Deportivo Guadalajara | 2:1 (2:0) | ||
| 04:30 | Club Tijuana | - | CF Monterrey | 1:1 (1:0) | ||
| 06.12.2021 | 19:00 | Atlas Guadalajara | - | Santos Laguna | 2:1 (1:1) | |
| 07.12.2021 | 00:00 | Deportivo Guadalajara | - | CF América | 0:0 (0:0) | |
| 02:00 | UANL Tigres | - | Cruz Azul | 4:0 (1:0) | ||
| 04:00 | CF Monterrey | - | Club Tijuana | 1:1 (1:1) | ||
| Halbfinale | ||||||
| 10.12.2021 | 18:00 | Atlas Guadalajara | - | CF Monterrey | 1:0 (0:0) | |
| 11.12.2021 | 03:00 | CF América | - | UANL Tigres | 2:1 (0:0) | |
| 14.12.2021 | 02:00 | UANL Tigres | - | CF América | 4:0 (0:0) | |
| 04:00 | CF Monterrey | - | Atlas Guadalajara | 2:1 (0:1) | ||
| Finale | ||||||
| 18.12.2021 | 04:00 | CF Monterrey | - | UANL Tigres | 2:2 (2:1) | |
| 21.12.2021 | 03:00 | UANL Tigres | - | CF Monterrey | 1:3 (0:0, 0:0, 0:0) i.E. | |
