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| H | Independiente del Valle | - | FBC Melgar | 3:0 (1:0) | ||
| R | FBC Melgar | - | Independiente del Valle | 0:3 (0:1) | ||
| H: 01.09.2022 02:30 | R: 08.09.2022 02:30 | Sieger: Independiente del Valle | ||||
| H | Atlético Goianiense | - | São Paulo FC | 3:1 (1:1) | ||
| R | São Paulo FC | - | Atlético Goianiense | 4:2 (1:0, 2:0) i.E. | ||
| H: 02.09.2022 02:30 | R: 09.09.2022 02:30 | Sieger: São Paulo FC | ||||
