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| 05.12.2021 | 12:00 | CD El Ejido 2012 | - | CD Marchamalo | 2:2 (2:2) | |
| 12:00 | Real Murcia | - | UD Melilla | 0:0 (0:0) | ||
| 12:00 | UD Socuéllamos | - | Mar Menor CF | 2:2 (1:0) | ||
| 12:00 | Levante UD B | - | Recreativo Granada | 1:1 (0:1) | ||
| 17:00 | UD Alzira | - | CS Puertollano CF | 2:1 (0:0) | ||
| 17:00 | CD Eldense | - | Atlético Mancha Real | 0:1 (0:1) | ||
| 17:00 | Hércules CF | - | Águilas FC | 2:1 (1:0) | ||
| 17:00 | CF La Nucía | - | CD Toledo | 2:0 (0:0) | ||
| 17:00 | CA Pulpileño | - | CF Intercity | 1:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF La Nucía | 14 | 8 | 4 | 2 | 19:7 | 12 | 28 |
| 2 |
|
CF Intercity | 14 | 7 | 5 | 2 | 20:9 | 11 | 26 |
| 3 |
|
Hércules CF | 14 | 7 | 4 | 3 | 20:16 | 4 | 25 |
| 4 |
|
Recreativo Granada | 14 | 5 | 7 | 2 | 17:13 | 4 | 22 |
| 5 |
|
UD Alzira | 14 | 5 | 6 | 3 | 16:11 | 5 | 21 |
| 6 |
|
UD Melilla | 14 | 6 | 3 | 5 | 16:15 | 1 | 21 |
| 7 |
|
CD Eldense | 14 | 5 | 6 | 3 | 15:14 | 1 | 21 |
| 8 |
|
Real Murcia | 14 | 5 | 6 | 3 | 14:13 | 1 | 21 |
| 9 |
|
Mar Menor CF | 14 | 6 | 3 | 5 | 14:15 | -1 | 21 |
| 10 |
|
Levante UD B | 14 | 5 | 5 | 4 | 18:9 | 9 | 20 |
| 11 |
|
CA Pulpileño | 14 | 5 | 5 | 4 | 14:17 | -3 | 20 |
| 12 |
|
Atlético Mancha Real | 14 | 5 | 3 | 6 | 9:12 | -3 | 18 |
| 13 |
|
Águilas FC | 14 | 4 | 5 | 5 | 13:12 | 1 | 17 |
| 14 |
|
CD El Ejido 2012 | 14 | 4 | 5 | 5 | 14:15 | -1 | 17 |
| 15 |
|
CS Puertollano CF | 14 | 3 | 3 | 8 | 13:19 | -6 | 12 |
| 16 |
|
UD Socuéllamos | 14 | 1 | 7 | 6 | 10:19 | -9 | 10 |
| 17 |
|
CD Toledo | 14 | 2 | 2 | 10 | 9:21 | -12 | 8 |
| 18 |
|
CD Marchamalo | 14 | 1 | 5 | 8 | 11:25 | -14 | 8 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
