29.10.2021 20:00 Accra Lions - Elmina Sharks 1:1 (0:0)
30.10.2021 17:00 Dreams FC - Asante Kotoko 1:3 (0:0)
31.10.2021 16:00 Bechem United - Medeama SC 4:0 (2:0)
16:00 Bibiani Gold Stars - Berekum Chelsea 1:0 (0:0)
16:00 Eleven Wonders - Ashanti Gold 0:1 (0:0)
16:00 Hearts of Oak - Legon Cities 0:0 (0:0)
16:00 Karela FC - Aduana Stars 1:1 (0:0)
16:00 King Faisal - WAFA 1:0 (0:0)
19:00 Real Tamale United - Great Olympics 1:1 (0:1)
# Mannschaft Sp. S. U. N. Tore Dif. Pk.
1 Bechem United, Ghana Bechem United 1 1 0 0 4:0 4 3
2 Asante Kotoko, Ghana Asante Kotoko 1 1 0 0 3:1 2 3
3 Ashanti Gold, Ghana Ashanti Gold 1 1 0 0 1:0 1 3
  Bibiani Gold Stars, Ghana Bibiani Gold Stars 1 1 0 0 1:0 1 3
  King Faisal, Ghana King Faisal 1 1 0 0 1:0 1 3
6 Accra Lions, Ghana Accra Lions 1 0 1 0 1:1 0 1
  Aduana Stars, Ghana Aduana Stars 1 0 1 0 1:1 0 1
  Elmina Sharks, Ghana Elmina Sharks 1 0 1 0 1:1 0 1
  Great Olympics, Ghana Great Olympics 1 0 1 0 1:1 0 1
  Karela FC, Ghana Karela FC 1 0 1 0 1:1 0 1
  Real Tamale United, Ghana Real Tamale United 1 0 1 0 1:1 0 1
12 Hearts of Oak, Ghana Hearts of Oak 1 0 1 0 0:0 0 1
  Legon Cities, Ghana Legon Cities 1 0 1 0 0:0 0 1
14 Berekum Chelsea, Ghana Berekum Chelsea 1 0 0 1 0:1 -1 0
  Eleven Wonders, Ghana Eleven Wonders 1 0 0 1 0:1 -1 0
  WAFA, Ghana WAFA 1 0 0 1 0:1 -1 0
17 Dreams FC, Ghana Dreams FC 1 0 0 1 1:3 -2 0
18 Medeama SC, Ghana Medeama SC 1 0 0 1 0:4 -4 0
  Champions League
  Abstieg