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| H | Atlas Guadalajara | - | CF Pachuca | 1:1 (1:0) | ||
| R | CF Pachuca | - | Atlas Guadalajara | 4:1 (1:0) | ||
| H: 24.04.2025 03:00 | R: 27.04.2025 05:00 | Sieger: CF Pachuca | ||||
| H | FC Juárez | - | CF América | 2:2 (0:0) | ||
| R | CF América | - | FC Juárez | 5:0 (4:0) | ||
| H: 24.04.2025 05:00 | R: 27.04.2025 03:00 | Sieger: CF América | ||||
| H | Deportivo Guadalajara | - | Pumas UNAM | 2:0 (0:0) | ||
| R | Pumas UNAM | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| H: 25.04.2025 03:00 | R: 27.04.2025 20:00 | Sieger: Deportivo Guadalajara | ||||
| H | UANL Tigres | - | CF Monterrey | 1:1 (1:0) | ||
| R | CF Monterrey | - | UANL Tigres | 1:1 (0:1) | ||
| H: 26.04.2025 04:00 | R: 29.04.2025 04:00 | |||||
