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| H | CF Pachuca | - | Deportivo Guadalajara | 0:0 (0:0) | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 0:2 (0:1) | ||
| H: 20.11.2024 16:00 | R: 23.11.2024 18:30 | Sieger: CF Pachuca | ||||
| H | Club León | - | Cruz Azul | 4:2 (3:0) | ||
| R | Cruz Azul | - | Club León | 2:1 (2:0) | ||
| H: 20.11.2024 18:30 | R: 23.11.2024 16:00 | Sieger: Club León | ||||
| H | Club Tijuana | - | UANL Tigres | 1:2 (1:0) | ||
| R | UANL Tigres | - | Club Tijuana | 2:1 (1:0) | ||
| H: 20.11.2024 21:45 | R: 23.11.2024 18:00 | Sieger: UANL Tigres | ||||
| H | Club Necaxa | - | Deportivo Toluca | 1:1 (1:1) | ||
| R | Deportivo Toluca | - | Club Necaxa | 0:1 (0:0) | ||
| H: 21.11.2024 17:00 | R: 24.11.2024 17:00 | Sieger: Club Necaxa | ||||
