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| 30.01.2022 | 11:00 | Ankaraspor | - | Afjet Afyonspor | 0:0 (0:0) | |
| 11:00 | Bayburt İl Özel İdare | - | Kahramanmaraşspor | 4:0 (3:0) | ||
| 11:00 | Bodrumspor | - | Sakaryaspor | 1:0 (1:0) | ||
| 11:00 | Çorum FK | - | Turgutluspor | 5:1 (3:0) | ||
| 11:00 | 1461 Trabzon FK | - | Adıyamanspor | 4:1 (1:0) | ||
| 11:00 | Inegölspor | - | Niğde Anadolu FK | 2:2 (1:0) | ||
| 11:00 | Sarıyer SK | - | Serik Belediyespor | 1:0 (0:0) | ||
| 11:00 | Sivas Belediyespor | - | Etimesgut Belediyespor | 1:1 (1:0) | ||
| 11:00 | Somaspor | - | Diyarbekirspor | 2:1 (1:1) | ||
| 11:00 | Vanspor FK | - | Ergene Velimeşe | 3:1 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 23 | 15 | 6 | 2 | 48:14 | 34 | 51 |
| 2 |
|
1461 Trabzon FK | 23 | 14 | 7 | 2 | 41:18 | 23 | 49 |
| 3 |
|
Sivas Belediyespor | 23 | 12 | 6 | 5 | 42:20 | 22 | 42 |
| 4 |
|
Afjet Afyonspor | 23 | 11 | 8 | 4 | 45:26 | 19 | 41 |
| 5 |
|
Bayburt İl Özel İdare | 23 | 12 | 5 | 6 | 33:22 | 11 | 41 |
| 6 |
|
Vanspor FK | 23 | 12 | 5 | 6 | 34:30 | 4 | 41 |
| 7 |
|
Bodrumspor | 23 | 12 | 4 | 7 | 34:20 | 14 | 40 |
| 8 |
|
Somaspor | 23 | 11 | 5 | 7 | 37:31 | 6 | 38 |
| 9 |
|
Çorum FK | 23 | 10 | 7 | 6 | 35:21 | 14 | 37 |
| 10 |
|
Ankaraspor | 23 | 9 | 8 | 6 | 37:26 | 11 | 35 |
| 11 |
|
Inegölspor | 23 | 9 | 4 | 10 | 29:33 | -4 | 31 |
| 12 |
|
Serik Belediyespor | 23 | 9 | 3 | 11 | 29:32 | -3 | 30 |
| 13 |
|
Etimesgut Belediyespor | 23 | 6 | 8 | 9 | 25:31 | -6 | 26 |
| 14 |
|
Diyarbekirspor | 23 | 7 | 4 | 12 | 25:28 | -3 | 25 |
| 15 |
|
Sarıyer SK | 23 | 7 | 3 | 13 | 25:34 | -9 | 24 |
| 16 |
|
Turgutluspor | 23 | 5 | 8 | 10 | 21:39 | -18 | 23 |
| 17 |
|
Adıyamanspor | 23 | 7 | 1 | 15 | 30:45 | -15 | 22 |
| 18 |
|
Ergene Velimeşe | 23 | 6 | 3 | 14 | 25:45 | -20 | 21 |
| 19 |
|
Kahramanmaraşspor | 23 | 3 | 4 | 16 | 15:55 | -40 | 13 |
| 20 |
|
Niğde Anadolu FK | 23 | 1 | 5 | 17 | 16:56 | -40 | 8 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
