 |
 |
| Viertelfinale | ||||||
|---|---|---|---|---|---|---|
| 17.11.2021 | 16:30 | CF Pachuca | - | Club León | 2:0 (0:0) | |
| 16:30 | Atlas Guadalajara | - | Mazatlán FC | 0:0 (0:0) | ||
| 18.11.2021 | 16:00 | UANL Tigres | - | CF América | 1:1 (0:0) | |
| 17:00 | Santos Laguna | - | Club Necaxa | 1:0 (0:0) | ||
| 20.11.2021 | 16:00 | Club León | - | CF Pachuca | 0:1 (0:1) | |
| 18:30 | Mazatlán FC | - | Atlas Guadalajara | 0:2 (0:0) | ||
| 21.11.2021 | 16:00 | Club Necaxa | - | Santos Laguna | 3:2 (1:1) | |
| 18:00 | CF América | - | UANL Tigres | 3:1 (2:0) | ||
| Halbfinale | ||||||
| 25.11.2021 | 16:30 | CF Pachuca | - | Club Necaxa | 1:2 (1:1) | |
| 18:30 | Atlas Guadalajara | - | CF América | 3:0 (2:0) | ||
| 28.11.2021 | 16:00 | Club Necaxa | - | CF Pachuca | 3:6 (1:1) | |
| 18:00 | CF América | - | Atlas Guadalajara | 3:2 (1:0) | ||
| Finale | ||||||
| 02.12.2021 | 01:00 | CF Pachuca | - | Atlas Guadalajara | 2:2 (1:1) | |
| 05.12.2021 | 00:00 | Atlas Guadalajara | - | CF Pachuca | 3:4 (0:0, 0:0, 0:0) i.E. | |
