| 1. Spieltag | 23.07.2021 | AS Trenčín | - | Zlaté Moravce | 4:0 |  |
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| 2. Spieltag | 31.07.2021 | Slovan Bratislava | - | AS Trenčín | 2:0 | ||||
| 3. Spieltag | 07.08.2021 | MFK Zemplín Michalovce | - | AS Trenčín | 1:2 | ||||
| 4. Spieltag | 13.08.2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Spieltag | 22.08.2021 | FC DAC 1904 | - | AS Trenčín | 1:1 | ||||
| 9. Spieltag | 24.09.2021 | FK Pohronie | - | AS Trenčín | 2:2 | ||||
| 10. Spieltag | 03.10.2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
| 16. Spieltag | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 18. Spieltag | 11.12.2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 19. Spieltag | 18.12.2021 | FK Senica | - | AS Trenčín | 1:0 | ||||
| 20. Spieltag | 12.02.2022 | AS Trenčín | - | FK Pohronie | 3:0 | ||||
| 21. Spieltag | 19.02.2022 | Spartak Trnava | - | AS Trenčín | 0:0 | ||||
| 22. Spieltag | 26.02.2022 | AS Trenčín | - | Tatran Liptovský Mikuláš | 2:2 |
Slowakei