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| H | Albinegros Orizaba | - | Indios Juárez | 1:0 (1:0) | ||
| R | Indios Juárez | - | Albinegros Orizaba | 0:1 (0:0) | ||
| H: 18.11.2010 02:00 | R: 21.11.2010 03:00 | Sieger: Albinegros Orizaba | ||||
| H | Club Irapuato | - | Alacranes de Durango | 2:0 (0:0) | ||
| R | Alacranes de Durango | - | Club Irapuato | 3:2 (3:1) | ||
| H: 18.11.2010 03:45 | R: 21.11.2010 02:00 | Sieger: Club Irapuato | ||||
| H | Veracruz (old) | - | Lobos BUAP | 1:1 (0:0) | ||
| R | Lobos BUAP | - | Veracruz (old) | 0:1 (0:1) | ||
| H: 19.11.2010 02:00 | R: 22.11.2010 00:00 | Sieger: Veracruz (old) | ||||
