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| H | Puebla FC | - | UANL Tigres | 2:1 | ||
| R | UANL Tigres | - | Puebla FC | 5:1 | ||
| H: 02.05.2018 19:00 | R: 05.05.2018 18:00 | Sieger: UANL Tigres | ||||
| H | CF Pachuca | - | Deportivo Guadalajara | 2:3 | ||
| R | Deportivo Guadalajara | - | CF Pachuca | 4:2 | ||
| H: 02.05.2018 19:00 | R: 05.05.2018 19:00 | Sieger: Deportivo Guadalajara | ||||
| H | Cruz Azul | - | CF América | 0:0 | ||
| R | CF América | - | Cruz Azul | 3:0 | ||
| H: 02.05.2018 23:00 | R: 05.05.2018 18:00 | Sieger: CF América | ||||
| H | Santos Laguna | - | Pumas UNAM | 1:2 | ||
| R | Pumas UNAM | - | Santos Laguna | 4:1 | ||
| H: 03.05.2018 18:00 | R: 06.05.2018 17:00 | Sieger: Pumas UNAM | ||||
