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| 19.02.2022 | 14:00 | FK Novi Pazar | - | FK Kolubara | 1:2 (0:1) | |
| 16:00 | FK Čukarički | - | Mladost Lučani | 1:0 (0:0) | ||
| 18:00 | TSC Bačka Topola | - | Spartak Subotica | 2:1 (1:1) | ||
| 20.02.2022 | 13:00 | Proleter Novi Sad | - | Crvena Zvezda | 1:2 (0:1) | |
| 15:30 | Partizan | - | FK Radnički 1923 | 2:0 (2:0) | ||
| 18:00 | FK Voždovac | - | Radnički Niš | 0:0 (0:0) | ||
| 21.02.2022 | 15:00 | FK Metalac | - | Vojvodina | 2:3 (1:1) | |
| 17:00 | Radnik Surdulica | - | FK Napredak | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 23 | 21 | 2 | 0 | 61:6 | 55 | 65 |
| 2 |
|
Crvena Zvezda | 23 | 19 | 3 | 1 | 55:14 | 41 | 60 |
| 3 |
|
FK Čukarički | 23 | 11 | 8 | 4 | 39:23 | 16 | 41 |
| 4 |
|
Vojvodina | 23 | 10 | 6 | 7 | 33:30 | 3 | 36 |
| 5 |
|
Radnički Niš | 23 | 7 | 10 | 6 | 27:24 | 3 | 31 |
| 6 |
|
FK Napredak | 23 | 9 | 4 | 10 | 26:26 | 0 | 31 |
| 7 |
|
FK Voždovac | 23 | 8 | 6 | 9 | 28:27 | 1 | 30 |
| 8 |
|
TSC Bačka Topola | 23 | 8 | 5 | 10 | 36:34 | 2 | 29 |
| 9 |
|
FK Kolubara | 23 | 9 | 2 | 12 | 26:45 | -19 | 29 |
| 10 |
|
Mladost Lučani | 23 | 8 | 3 | 12 | 26:32 | -6 | 27 |
| 11 |
|
Spartak Subotica | 23 | 7 | 6 | 10 | 25:38 | -13 | 27 |
| 12 |
|
Proleter Novi Sad | 23 | 8 | 3 | 12 | 18:36 | -18 | 27 |
| 13 |
|
Radnik Surdulica | 23 | 5 | 10 | 8 | 18:25 | -7 | 25 |
| 14 |
|
FK Metalac | 23 | 5 | 4 | 14 | 28:44 | -16 | 19 |
| 15 |
|
FK Novi Pazar | 23 | 3 | 8 | 12 | 21:39 | -18 | 17 |
| 16 |
|
FK Radnički 1923 | 23 | 4 | 4 | 15 | 20:44 | -24 | 16 |
| Playoffs | |
| Relegation |
