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| 01.04.2022 | 16:15 | FK Novi Pazar | - | FK Napredak | 1:0 (1:0) | |
| 18:30 | FK Kolubara | - | Mladost Lučani | 2:2 (1:1) | ||
| 02.04.2022 | 14:00 | Partizan | - | TSC Bačka Topola | 2:0 (2:0) | |
| 14:00 | FK Radnički 1923 | - | Vojvodina | 3:2 (2:0) | ||
| 16:15 | Radnički Niš | - | Crvena Zvezda | 1:5 (1:1) | ||
| 18:30 | FK Metalac | - | Spartak Subotica | 2:0 (1:0) | ||
| 04.04.2022 | 16:15 | FK Voždovac | - | Radnik Surdulica | 4:0 (1:0) | |
| 18:30 | Proleter Novi Sad | - | FK Čukarički | 1:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Crvena Zvezda | 29 | 25 | 3 | 1 | 75:16 | 59 | 78 |
| 2 |
|
Partizan | 29 | 25 | 3 | 1 | 68:10 | 58 | 78 |
| 3 |
|
FK Čukarički | 29 | 14 | 11 | 4 | 48:27 | 21 | 53 |
| 4 |
|
FK Voždovac | 29 | 11 | 7 | 11 | 40:35 | 5 | 40 |
| 5 |
|
Radnički Niš | 29 | 9 | 13 | 7 | 32:31 | 1 | 40 |
| 6 |
|
TSC Bačka Topola | 29 | 10 | 8 | 11 | 42:40 | 2 | 38 |
| 7 |
|
Vojvodina | 29 | 10 | 6 | 13 | 36:39 | -3 | 36 |
| 8 |
|
FK Napredak | 29 | 9 | 7 | 13 | 30:36 | -6 | 34 |
| 9 |
|
FK Kolubara | 29 | 10 | 4 | 15 | 29:52 | -23 | 34 |
| 10 |
|
Mladost Lučani | 29 | 9 | 6 | 14 | 36:44 | -8 | 33 |
| 11 |
|
Radnik Surdulica | 29 | 7 | 12 | 10 | 22:31 | -9 | 33 |
| 12 |
|
Spartak Subotica | 29 | 8 | 7 | 14 | 31:46 | -15 | 31 |
| 13 |
|
FK Radnički 1923 | 29 | 8 | 6 | 15 | 26:46 | -20 | 30 |
| 14 |
|
Proleter Novi Sad | 29 | 8 | 5 | 16 | 22:47 | -25 | 29 |
| 15 |
|
FK Metalac | 29 | 7 | 6 | 16 | 36:51 | -15 | 27 |
| 16 |
|
FK Novi Pazar | 29 | 5 | 10 | 14 | 25:47 | -22 | 25 |
| Playoffs | |
| Relegation |
