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| 16.04.2022 | 18:00 | FK Senica | - | Tatran Liptovský Mikuláš | 0:3 (0:1) | |
| 18:00 | FK Pohronie | - | AS Trenčín | 1:1 (1:0) | ||
| 18.04.2022 | 14:00 | Zlaté Moravce | - | MFK Zemplín Michalovce | 1:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Trenčín | 28 | 10 | 8 | 10 | 46:39 | 7 | 38 |
| 2 |
|
Tatran Liptovský Mikuláš | 28 | 9 | 7 | 12 | 37:49 | -12 | 34 |
| 3 |
|
MFK Zemplín Michalovce | 28 | 10 | 3 | 15 | 26:37 | -11 | 33 |
| 4 |
|
FK Senica | 28 | 9 | 6 | 13 | 29:46 | -17 | 33 |
| 5 |
|
Zlaté Moravce | 28 | 6 | 8 | 14 | 30:45 | -15 | 26 |
| 6 |
|
FK Pohronie | 28 | 2 | 6 | 20 | 22:55 | -33 | 12 |
| Playoffs | |
| Abstieg |
