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| 21.01.2022 | 17:00 | Samsunspor | - | Kocaelispor | 3:0 (2:0) | |
| 22.01.2022 | 11:30 | Manisa FK | - | Gençlerbirliği | 3:1 (0:1) | |
| 11:30 | Ümraniyespor | - | Menemen Belediyespor | 2:1 (1:0) | ||
| 14:00 | Altınordu FK | - | İstanbulspor AŞ | 0:5 (0:1) | ||
| 17:00 | MKE Ankaragücü | - | Denizlispor | 2:1 (0:0) | ||
| 23.01.2022 | 11:30 | Adanaspor | - | Keçiörengücü | 0:1 (0:1) | |
| 11:30 | Bandırmaspor | - | BB Erzurumspor | 2:1 (1:1) | ||
| 02.03.2022 | 12:30 | Boluspor | - | Tuzlaspor | 0:1 (0:0) | |
| 10.03.2022 | 18:00 | Eyüpspor | - | Bursaspor | 3:0 (2:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 21 | 14 | 3 | 4 | 34:16 | 18 | 45 |
| 2 |
|
Ümraniyespor | 21 | 14 | 3 | 4 | 37:17 | 20 | 45 |
| 3 |
|
Eyüpspor | 21 | 11 | 6 | 4 | 33:22 | 11 | 39 |
| 4 |
|
BB Erzurumspor | 21 | 11 | 5 | 5 | 34:24 | 10 | 38 |
| 5 |
|
Bandırmaspor | 21 | 11 | 3 | 7 | 34:21 | 13 | 36 |
| 6 |
|
İstanbulspor AŞ | 21 | 11 | 3 | 7 | 35:25 | 10 | 36 |
| 7 |
|
Samsunspor | 20 | 9 | 6 | 5 | 31:23 | 8 | 33 |
| 8 |
|
Adanaspor | 21 | 9 | 5 | 7 | 26:21 | 5 | 32 |
| 9 |
|
Tuzlaspor | 21 | 8 | 6 | 7 | 22:20 | 2 | 30 |
| 10 |
|
Manisa FK | 21 | 8 | 4 | 9 | 25:27 | -2 | 28 |
| 11 |
|
Keçiörengücü | 21 | 7 | 5 | 9 | 28:32 | -4 | 26 |
| 12 |
|
Gençlerbirliği | 21 | 8 | 2 | 11 | 24:32 | -8 | 26 |
| 13 |
|
Boluspor | 20 | 6 | 6 | 8 | 21:22 | -1 | 24 |
| 14 |
|
Kocaelispor | 21 | 7 | 3 | 11 | 20:28 | -8 | 24 |
| 15 |
|
Menemen Belediyespor | 21 | 5 | 8 | 8 | 24:35 | -11 | 23 |
| 16 |
|
Altınordu FK | 21 | 7 | 1 | 13 | 27:45 | -18 | 22 |
| 17 |
|
Bursaspor | 21 | 5 | 5 | 11 | 23:34 | -11 | 20 |
| 18 |
|
Denizlispor | 21 | 5 | 4 | 12 | 20:32 | -12 | 19 |
| 19 |
|
Balıkesirspor | 20 | 2 | 2 | 16 | 14:36 | -22 | 8 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
