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| 03.04.2022 | 12:00 | AD Ceuta FC | - | UD Tamaraceite | 2:2 (1:1) | |
| 12:00 | Cádiz CF B | - | UD Montijo | 2:2 (0:1) | ||
| 13:00 | CF Panadería Pulido | - | UD San Fernando | 1:1 (1:1) | ||
| 13:00 | UD Las Palmas B | - | CD Mensajero | 2:1 (2:1) | ||
| 17:00 | Vélez CF | - | Don Benito | 0:0 (0:0) | ||
| 17:00 | CF Villanovense | - | CD San Roque | 0:0 (0:0) | ||
| 17:30 | CP Cacereño | - | Córdoba CF | 2:2 (1:1) | ||
| 18:00 | Mérida AD | - | Antequera CF | 1:1 (0:1) | ||
| 18:00 | Xerez DFC | - | CD Coria | 1:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Córdoba CF | 28 | 20 | 6 | 2 | 70:22 | 48 | 66 |
| 2 |
|
CP Cacereño | 28 | 15 | 9 | 4 | 40:26 | 14 | 54 |
| 3 |
|
Mérida AD | 28 | 13 | 8 | 7 | 40:22 | 18 | 47 |
| 4 |
|
AD Ceuta FC | 28 | 12 | 11 | 5 | 37:24 | 13 | 47 |
| 5 |
|
CF Villanovense | 28 | 12 | 7 | 9 | 31:20 | 11 | 43 |
| 6 |
|
UD Montijo | 28 | 12 | 7 | 9 | 32:24 | 8 | 43 |
| 7 |
|
CD San Roque | 28 | 10 | 9 | 9 | 27:23 | 4 | 39 |
| 8 |
|
Vélez CF | 28 | 11 | 6 | 11 | 31:31 | 0 | 39 |
| 9 |
|
CD Coria | 28 | 10 | 8 | 10 | 29:32 | -3 | 38 |
| 10 |
|
Cádiz CF B | 28 | 8 | 11 | 9 | 22:30 | -8 | 35 |
| 11 |
|
Xerez DFC | 28 | 9 | 8 | 11 | 22:35 | -13 | 35 |
| 12 |
|
Don Benito | 28 | 8 | 9 | 11 | 35:36 | -1 | 33 |
| 13 |
|
Antequera CF | 28 | 7 | 10 | 11 | 25:32 | -7 | 31 |
| 14 |
|
UD Las Palmas B | 28 | 7 | 9 | 12 | 33:43 | -10 | 30 |
| 15 |
|
CD Mensajero | 28 | 5 | 14 | 9 | 26:37 | -11 | 29 |
| 16 |
|
UD San Fernando | 28 | 6 | 7 | 15 | 27:43 | -16 | 25 |
| 17 |
|
CF Panadería Pulido | 28 | 5 | 9 | 14 | 24:44 | -20 | 24 |
| 18 |
|
UD Tamaraceite | 28 | 5 | 6 | 17 | 27:54 | -27 | 21 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
