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| 09.10.2021 | 17:00 | Mazatlán FC | - | Santos Laguna | 0:2 (0:2) | |
| 18:15 | UANL Tigres | - | Club Necaxa | 3:1 (2:0) | ||
| 18:30 | Gallos Blancos | - | Deportivo Toluca | 0:0 (0:0) | ||
| 18:30 | CF Monterrey | - | Atlético San Luis | 4:0 (2:0) | ||
| 19:00 | Deportivo Guadalajara | - | Club León | 3:0 (1:0) | ||
| 19:00 | Pumas UNAM | - | CF Pachuca | 1:1 (0:1) | ||
| 19:30 | FC Juárez | - | Cruz Azul | 4:3 (3:1) | ||
| 21:45 | Club Tijuana | - | Puebla FC | 5:0 (2:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 4 | 3 | 1 | 0 | 16:4 | 12 | 10 |
| 2 |
|
CF América | 3 | 3 | 0 | 0 | 10:6 | 4 | 9 |
| 3 |
|
Pumas UNAM | 4 | 2 | 1 | 1 | 10:5 | 5 | 7 |
| 4 |
|
FC Juárez | 3 | 2 | 0 | 1 | 5:8 | -3 | 6 |
| 5 |
|
Deportivo Toluca | 4 | 1 | 1 | 2 | 4:7 | -3 | 4 |
| 6 |
|
Club Tijuana | 3 | 1 | 0 | 2 | 6:5 | 1 | 3 |
| 7 |
|
Cruz Azul | 4 | 1 | 0 | 3 | 9:14 | -5 | 3 |
| 8 |
|
Puebla FC | 4 | 1 | 0 | 3 | 2:11 | -9 | 3 |
| 9 |
|
Gallos Blancos | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 4 | 3 | 0 | 1 | 11:6 | 5 | 9 |
| 2 |
|
UANL Tigres | 4 | 2 | 1 | 1 | 10:4 | 6 | 7 |
| 3 |
|
Santos Laguna | 4 | 2 | 1 | 1 | 5:5 | 0 | 7 |
| 4 |
|
CF Monterrey | 3 | 2 | 0 | 1 | 9:3 | 6 | 6 |
| 5 |
|
Atlas Guadalajara | 3 | 2 | 0 | 1 | 6:5 | 1 | 6 |
| 6 |
|
Club León | 3 | 1 | 1 | 1 | 4:6 | -2 | 4 |
| 7 |
|
Club Necaxa | 3 | 1 | 0 | 2 | 5:5 | 0 | 3 |
| 8 |
|
Mazatlán FC | 4 | 0 | 2 | 2 | 4:9 | -5 | 2 |
| 9 |
|
Atlético San Luis | 4 | 0 | 1 | 3 | 3:14 | -11 | 1 |
