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| 27.08.2022 | 18:00 | Puebla FC | - | CF Pachuca | 1:1 (1:1) | |
| 18:30 | Cruz Azul | - | Pumas UNAM | 0:4 (0:0) | ||
| 18:30 | Club León | - | Atlas Guadalajara | 5:0 (4:0) | ||
| 19:45 | CF América | - | FC Juárez | 5:0 (1:0) | ||
| 21:45 | Club Tijuana | - | Mazatlán FC | 4:0 (3:0) | ||
| 23:00 | CF Monterrey | - | Atlético San Luis | 5:1 (2:0) | ||
| 28.08.2022 | 18:15 | Deportivo Guadalajara | - | Santos Laguna | 1:1 (0:0) | |
| 13.09.2022 | 18:30 | Gallos Blancos | - | Club Necaxa | 0:0 (0:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 9 | 8 | 1 | 0 | 23:10 | 13 | 25 |
| 2 |
|
Club Necaxa | 9 | 5 | 1 | 3 | 16:5 | 11 | 16 |
| 3 |
|
Deportivo Toluca | 8 | 4 | 3 | 1 | 17:12 | 5 | 15 |
| 4 |
|
CF Pachuca | 9 | 3 | 4 | 2 | 12:8 | 4 | 13 |
| 5 |
|
Gallos Blancos | 9 | 3 | 3 | 3 | 14:10 | 4 | 12 |
| 6 |
|
CF América | 9 | 3 | 2 | 4 | 17:17 | 0 | 11 |
| 7 |
|
Cruz Azul | 9 | 3 | 1 | 5 | 16:22 | -6 | 10 |
| 8 |
|
Puebla FC | 9 | 2 | 1 | 6 | 11:18 | -7 | 7 |
| 9 |
|
FC Juárez | 9 | 1 | 0 | 8 | 11:35 | -24 | 3 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 9 | 7 | 1 | 1 | 29:9 | 20 | 22 |
| 2 |
|
CF Monterrey | 9 | 6 | 3 | 0 | 27:11 | 16 | 21 |
| 3 |
|
Atlas Guadalajara | 9 | 4 | 3 | 2 | 21:13 | 8 | 15 |
| 4 |
|
Club León | 9 | 4 | 1 | 4 | 17:11 | 6 | 13 |
| 5 |
|
Deportivo Guadalajara | 9 | 4 | 1 | 4 | 12:12 | 0 | 13 |
| 6 |
|
UANL Tigres | 8 | 3 | 2 | 3 | 12:17 | -5 | 11 |
| 7 |
|
Santos Laguna | 9 | 2 | 3 | 4 | 21:19 | 2 | 9 |
| 8 |
|
Atlético San Luis | 9 | 2 | 0 | 7 | 12:39 | -27 | 6 |
| 9 |
|
Mazatlán FC | 9 | 1 | 0 | 8 | 9:29 | -20 | 3 |
| Playoffs | |
| Playoffs |
