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| 23.04.2022 | 16:00 | Santos Laguna | - | UANL Tigres | 5:0 (3:0) | |
| 16:00 | Pumas UNAM | - | Deportivo Toluca | 3:4 (1:4) | ||
| 16:00 | Atlas Guadalajara | - | Deportivo Guadalajara | 2:2 (2:2) | ||
| 16:00 | Club León | - | Club Tijuana | 1:0 (1:0) | ||
| 19:00 | Club Necaxa | - | FC Juárez | 5:0 (0:0) | ||
| 19:30 | Mazatlán FC | - | Atlético San Luis | 2:1 (1:1) | ||
| 23:00 | Puebla FC | - | Cruz Azul | 2:3 (0:2) | ||
| 23:00 | CF América | - | CF Pachuca | 2:0 (1:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 14 | 8 | 4 | 2 | 26:19 | 7 | 28 |
| 2 |
|
Deportivo Toluca | 15 | 8 | 2 | 5 | 37:22 | 15 | 26 |
| 3 |
|
Pumas UNAM | 14 | 8 | 2 | 4 | 23:12 | 11 | 26 |
| 4 |
|
Cruz Azul | 15 | 8 | 2 | 5 | 32:22 | 10 | 26 |
| 5 |
|
CF América | 14 | 8 | 1 | 5 | 20:15 | 5 | 25 |
| 6 |
|
Puebla FC | 14 | 5 | 2 | 7 | 23:22 | 1 | 17 |
| 7 |
|
CF Pachuca | 14 | 4 | 5 | 5 | 25:26 | -1 | 17 |
| 8 |
|
Gallos Blancos | 14 | 2 | 3 | 9 | 9:28 | -19 | 9 |
| 9 |
|
FC Juárez | 14 | 2 | 1 | 11 | 15:44 | -29 | 7 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 14 | 10 | 3 | 1 | 35:13 | 22 | 33 |
| 2 |
|
Atlas Guadalajara | 14 | 8 | 4 | 2 | 33:17 | 16 | 28 |
| 3 |
|
Santos Laguna | 14 | 8 | 2 | 4 | 25:14 | 11 | 26 |
| 4 |
|
UANL Tigres | 14 | 6 | 4 | 4 | 18:21 | -3 | 22 |
| 5 |
|
Club León | 14 | 6 | 2 | 6 | 18:21 | -3 | 20 |
| 6 |
|
CF Monterrey | 14 | 3 | 6 | 5 | 21:23 | -2 | 15 |
| 7 |
|
Club Tijuana | 14 | 4 | 1 | 9 | 11:22 | -11 | 13 |
| 8 |
|
Mazatlán FC | 15 | 3 | 3 | 9 | 18:36 | -18 | 12 |
| 9 |
|
Atlético San Luis | 15 | 2 | 3 | 10 | 15:27 | -12 | 9 |
| Playoffs | |
| Playoffs |
