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| 01.10.2022 | 17:00 | FC Juárez | - | Club Necaxa | 2:1 (0:1) | |
| 17:30 | Puebla FC | - | Gallos Blancos | 1:2 (0:2) | ||
| 18:00 | CF Pachuca | - | Pumas UNAM | 3:1 (2:0) | ||
| 19:30 | Mazatlán FC | - | Santos Laguna | 0:4 (0:2) | ||
| 23:00 | CF América | - | Deportivo Toluca | 0:4 (0:3) | ||
| 23:00 | CF Monterrey | - | UANL Tigres | 1:3 (1:0) | ||
| 02.10.2022 | 14:45 | Atlético San Luis | - | Atlas Guadalajara | 0:2 (0:1) | |
| 12.10.2022 | 19:00 | Club Tijuana | - | Club León | 4:1 (2:1) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 13 | 7 | 2 | 4 | 35:24 | 11 | 23 |
| 2 |
|
CF América | 13 | 6 | 4 | 3 | 25:21 | 4 | 22 |
| 3 |
|
Club Necaxa | 13 | 6 | 3 | 4 | 31:20 | 11 | 21 |
| 4 |
|
Gallos Blancos | 14 | 6 | 2 | 6 | 18:25 | -7 | 20 |
| 5 |
|
Cruz Azul | 13 | 5 | 4 | 4 | 28:22 | 6 | 19 |
| 6 |
|
CF Pachuca | 14 | 6 | 1 | 7 | 22:23 | -1 | 19 |
| 7 |
|
Pumas UNAM | 13 | 5 | 3 | 5 | 16:19 | -3 | 18 |
| 8 |
|
FC Juárez | 14 | 4 | 5 | 5 | 20:24 | -4 | 17 |
| 9 |
|
Puebla FC | 13 | 2 | 2 | 9 | 17:34 | -17 | 8 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 13 | 9 | 3 | 1 | 27:13 | 14 | 30 |
| 2 |
|
Santos Laguna | 13 | 9 | 1 | 3 | 24:11 | 13 | 28 |
| 3 |
|
CF Monterrey | 13 | 8 | 1 | 4 | 31:16 | 15 | 25 |
| 4 |
|
Mazatlán FC | 14 | 7 | 1 | 6 | 18:23 | -5 | 22 |
| 5 |
|
Atlas Guadalajara | 13 | 6 | 2 | 5 | 18:14 | 4 | 20 |
| 6 |
|
UANL Tigres | 13 | 5 | 1 | 7 | 14:17 | -3 | 16 |
| 7 |
|
Atlético San Luis | 14 | 4 | 3 | 7 | 21:26 | -5 | 15 |
| 8 |
|
Club Tijuana | 13 | 4 | 2 | 7 | 15:22 | -7 | 14 |
| 9 |
|
Club León | 14 | 0 | 2 | 12 | 18:44 | -26 | 2 |
| Playoffs | |
| Playoffs |
