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| 08.11.2005 | Olympiakos Volou | - | Panionios GSS | 0:2 | ||
| Ilisiakos | - | AO Egaleo | 0:2 | |||
| Niki Volou FC | - | OFI Heraklion | 3:2 i.E. | |||
| PAE Thraki Alexandroupoli | - | Ionikos Nikea | 4:5 i.E. | |||
| PAS Giannina | - | AEK Athen | 0:3 | |||
| Veria FC | - | Skoda Xanthi | 0:2 | |||
| Agrotikos Asteras | - | PAOK Saloniki | 5:4 i.E. | |||
| Panserraikos | - | AE Lárissa | 0:1 | |||
| Ethnikos Piraeus | - | GS Kallithea | 4:2 i.E. | |||
| Asteras Tripolis | - | Apollon Kalamarias | 2:3 i.E. | |||
| Panthrakikos | - | Akratitos Liosion | 5:6 i.E. | |||
| Ergotelis | - | Panathinaikos | 1:0 | |||
| Panachaiki GE | - | Iraklis Saloniki | 4:2 i.E. | |||
| Paniliakos Pyrgos | - | Olympiakos Piraeus | 0:4 | |||
| Thrasyvoulos Fylis | - | Atromitos | 2:0 | |||
| Ethnikos Asteras | - | Levadiakos | 1:0 |
