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| H | CF América | - | Santos Laguna | 1:2 (1:1) | ||
| R | Santos Laguna | - | CF América | 3:3 (1:0) | ||
| H: 26.11.2010 02:00 | R: 29.11.2010 01:00 | Sieger: Santos Laguna | ||||
| H | Pumas UNAM | - | CF Monterrey | 0:0 (0:0) | ||
| R | CF Monterrey | - | Pumas UNAM | 2:0 (0:0) | ||
| H: 26.11.2010 04:00 | R: 29.11.2010 03:00 | Sieger: CF Monterrey | ||||
