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| H | Club Olimpia | - | Grêmio Porto Alegre | 2:3 (2:1) | ||
| R | Grêmio Porto Alegre | - | Club Olimpia | 3:0 (2:0) | ||
| H: 23.04.2003 02:10 | R: 09.05.2003 02:40 | Sieger: Grêmio Porto Alegre | ||||
| H | Cerro Porteño | - | Independiente Medellín | 0:1 (0:1) | ||
| R | Independiente Medellín | - | Cerro Porteño | 4:2 (0:0, 0:1, 0:1) i.E. | ||
| H: 24.04.2003 00:10 | R: 07.05.2003 01:10 | Sieger: Independiente Medellín | ||||
| H | Nacional | - | Santos FC | 4:4 (0:2) | ||
| R | Santos FC | - | Nacional | 2:2 (1:2) | ||
| H: 24.04.2003 02:40 | R: 08.05.2003 02:40 | Sieger: Santos FC | ||||
| H | Boca Juniors | - | Paysandu - PA | 0:1 (0:0) | ||
| R | Paysandu - PA | - | Boca Juniors | 2:4 (0:1) | ||
| H: 25.04.2003 02:10 | R: 16.05.2003 02:40 | Sieger: Boca Juniors | ||||
| H | Pumas UNAM | - | Cobreloa | 0:1 (0:0) | ||
| R | Cobreloa | - | Pumas UNAM | 0:0 (0:0) | ||
| H: 25.04.2003 04:30 | R: 09.05.2003 00:10 | Sieger: Cobreloa | ||||
| H | América de Cali | - | Racing Club | 1:1 (1:0) | ||
| R | Racing Club | - | América de Cali | 5:6 (0:0, 0:0, 0:0) i.E. | ||
| H: 30.04.2003 02:40 | R: 14.05.2003 01:10 | Sieger: América de Cali | ||||
| H | River Plate | - | Corinthians SP | 2:1 (0:0) | ||
| R | Corinthians SP | - | River Plate | 1:2 (1:1) | ||
| H: 01.05.2003 20:30 | R: 15.05.2003 02:40 | Sieger: River Plate | ||||
| H | Cruz Azul | - | Deportivo Cali | 0:0 (0:0) | ||
| R | Deportivo Cali | - | Cruz Azul | 2:3 (0:0, 0:0, 0:0) i.E. | ||
| H: 07.05.2003 00:40 | R: 14.05.2003 02:40 | Sieger: Cruz Azul | ||||
