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| 16.04.2022 | 18:00 | Bergerac Foot | - | Canet Roussillon | 2:1 (1:0) | |
| 18:00 | FC Nantes (CFA) | - | Angoulême CFC | 0:0 (0:0) | ||
| 18:00 | Montpellier HSC (CFA) | - | Stade Montois | 4:0 (0:0) | ||
| 18:00 | Angers SCO II | - | Le Puy Foot 43 | 0:2 (0:0) | ||
| 18:00 | US Colomiers | - | Trélissac FC | 1:1 (0:0) | ||
| 18:00 | Vendée Les Herbiers | - | Bourges Foot 18 | 0:1 (0:1) | ||
| 18:00 | FC Chamalières | - | AS Béziers | 0:2 (0:1) | ||
| 19:00 | Andrézieux-Bouthéon FC | - | Moulins Yzeure Foot | 2:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bergerac Foot | 25 | 14 | 8 | 3 | 30:13 | 17 | 50 |
| 2 |
|
Andrézieux-Bouthéon FC | 25 | 14 | 5 | 6 | 35:20 | 15 | 47 |
| 3 |
|
Le Puy Foot 43 | 25 | 13 | 7 | 5 | 32:15 | 17 | 46 |
| 4 |
|
Angoulême CFC | 25 | 12 | 8 | 5 | 29:18 | 11 | 44 |
| 5 |
|
Bourges Foot 18 | 25 | 12 | 5 | 8 | 34:22 | 12 | 41 |
| 6 |
|
AS Béziers | 25 | 9 | 8 | 8 | 31:27 | 4 | 35 |
| 7 |
|
Moulins Yzeure Foot | 25 | 8 | 10 | 7 | 24:24 | 0 | 34 |
| 8 |
|
Vendée Les Herbiers | 25 | 9 | 7 | 9 | 28:29 | -1 | 34 |
| 9 |
|
FC Nantes (CFA) | 25 | 8 | 9 | 8 | 28:27 | 1 | 33 |
| 10 |
|
Angers SCO II | 25 | 6 | 11 | 8 | 23:25 | -2 | 29 |
| 11 |
|
Trélissac FC | 25 | 7 | 7 | 11 | 22:24 | -2 | 28 |
| 12 |
|
Canet Roussillon | 25 | 11 | 5 | 9 | 23:29 | -6 | 27 |
| 13 |
|
Montpellier HSC (CFA) | 25 | 7 | 6 | 12 | 29:36 | -7 | 27 |
| 14 |
|
FC Chamalières | 25 | 7 | 6 | 12 | 26:34 | -8 | 27 |
| 15 |
|
US Colomiers | 25 | 5 | 9 | 11 | 25:34 | -9 | 24 |
| 16 |
|
Stade Montois | 25 | 1 | 3 | 21 | 15:57 | -42 | 6 |
| Aufstieg | |
| Abstieg |
