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| H | UANL Tigres | - | Monarcas Morelia | 3:2 (1:1) | ||
| R | Monarcas Morelia | - | UANL Tigres | 2:1 (2:0) | ||
| H: 12.05.2005 02:00 | R: 15.05.2005 02:00 | Sieger: Monarcas Morelia | ||||
| H | CF Monterrey | - | Cruz Azul | 0:0 (0:0) | ||
| R | Cruz Azul | - | CF Monterrey | 3:3 (1:2) | ||
| H: 12.05.2005 04:00 | R: 15.05.2005 01:00 | Sieger: CF Monterrey | ||||
| H | Santos Laguna | - | CF América | 2:2 (0:1) | ||
| R | CF América | - | Santos Laguna | 1:1 (1:0) | ||
| H: 13.05.2005 02:00 | R: 16.05.2005 01:00 | Sieger: CF América | ||||
| H | Club Necaxa | - | UAG Tecos | 0:2 (0:2) | ||
| R | UAG Tecos | - | Club Necaxa | 2:1 (1:1) | ||
| H: 13.05.2005 04:00 | R: 15.05.2005 23:00 | Sieger: UAG Tecos | ||||
