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| H | Seattle Sounders | - | Real Salt Lake | 0:0 (0:0) | ||
| R | Real Salt Lake | - | Seattle Sounders | 0:1 (0:0) | ||
| H: 03.11.2012 03:00 | R: 09.11.2012 04:00 | Sieger: Seattle Sounders | ||||
| H | D.C. United | - | New York RB | 1:1 (0:0) | ||
| R | New York RB | - | D.C. United | 0:1 (0:0) | ||
| H: 04.11.2012 01:00 | R: 09.11.2012 01:30 | Sieger: D.C. United | ||||
| H | Houston Dynamo | - | Sporting Kansas City | 2:0 (1:0) | ||
| R | Sporting Kansas City | - | Houston Dynamo | 1:0 (0:0) | ||
| H: 04.11.2012 21:30 | R: 08.11.2012 03:00 | Sieger: Houston Dynamo | ||||
| H | Los Angeles Galaxy | - | San Jose Earthquakes | 0:1 (0:0) | ||
| R | San Jose Earthquakes | - | Los Angeles Galaxy | 1:3 (0:3) | ||
| H: 05.11.2012 03:00 | R: 08.11.2012 05:00 | Sieger: Los Angeles Galaxy | ||||
