| Gruppe C | 08.09.2022 | PFC Ludogorets Razgrad | - | AS Roma | 2:1 | ||||
| Gruppe C | 15.09.2022 | AS Roma | - | HJK Helsinki | 3:0 | ||||
| Gruppe C | 06.10.2022 | AS Roma | - | Real Betis | 1:2 | ||||
| Gruppe C | 13.10.2022 | Real Betis | - | AS Roma | 1:1 | ||||
| Gruppe C | 27.10.2022 | HJK Helsinki | - | AS Roma | 1:2 | ||||
| Gruppe C | 03.11.2022 | AS Roma | - | PFC Ludogorets Razgrad | 3:1 | ||||
| Playoffs | 16.02.2023 | RB Salzburg | - | AS Roma | 1:0 | ||||
| Playoffs | 23.02.2023 | AS Roma | - | RB Salzburg | 2:0 | ||||
| Achtelfinale | 09.03.2023 | AS Roma | - | Real Sociedad | 2:0 | ||||
| Achtelfinale | 16.03.2023 | Real Sociedad | - | AS Roma | 0:0 |  |
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| Viertelfinale | 13.04.2023 | Feyenoord | - | AS Roma | 1:0 | ||||
| Viertelfinale | 20.04.2023 | AS Roma | - | Feyenoord | 4:1 n.V. | ||||
| Halbfinale | 18.05.2023 | Bayer Leverkusen | - | AS Roma | 0:0 | ||||
| Finale | 31.05.2023 | Sevilla FC | - | AS Roma | 4:1 i.E. |
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