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| 27.08.2022 | 00:10 | Instituto de Córdoba | - | Villa Dálmine | 0:0 (0:0) | |
| 02:05 | San Martín de Tucumán | - | Güemes de SdE | 4:0 (1:0) | ||
| 19:10 | Ferro Carril Oeste | - | Flandria | 1:2 (0:2) | ||
| 20:00 | Brown de Adrogué | - | Gimnasia de Mendoza | 1:2 (0:0) | ||
| 20:00 | Tristan Suárez | - | Deportivo Riestra | 1:1 (0:1) | ||
| 20:00 | Deportivo Maipú | - | Deportivo Madryn | 2:2 (0:2) | ||
| 21:30 | Mitre de SdE | - | Gimnasia de Jujuy | 2:0 (1:0) | ||
| 22:00 | Chacarita Juniors | - | San Telmo | 4:1 (2:0) | ||
| 23:10 | Agropecuario Argentino | - | Belgrano de Córdoba | 0:1 (0:0) | ||
| 28.08.2022 | 01:30 | Ramón Santamarina | - | Atlanta | 1:2 (0:0) | |
| 18:35 | Almagro | - | Alvarado | 1:0 (0:0) | ||
| 20:00 | Guillermo Brown | - | Chaco For Ever | 1:0 (0:0) | ||
| 21:00 | Independiente Rivadavia | - | Temperley | 1:1 (1:0) | ||
| 29.08.2022 | 00:30 | Atlético Rafaela | - | San Martín de San Juan | 3:0 (2:0) | |
| 20:00 | Sacachispas | - | Almirante Brown | 0:1 (0:0) | ||
| 30.08.2022 | 00:15 | Defensores de Belgrano | - | All Boys | 1:1 (0:1) | |
| 01:35 | Quilmes | - | Deportivo Morón | 2:1 (1:1) | ||
| 02:00 | Nueva Chicago | - | Estudiantes de Río Cuarto | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 30 | 19 | 7 | 4 | 34:19 | 15 | 64 |
| 2 |
|
San Martín de Tucumán | 30 | 14 | 13 | 3 | 38:18 | 20 | 55 |
| 3 |
|
Instituto de Córdoba | 30 | 14 | 11 | 5 | 35:21 | 14 | 53 |
| 4 |
|
Gimnasia de Mendoza | 30 | 13 | 12 | 5 | 33:14 | 19 | 51 |
| 5 |
|
All Boys | 30 | 12 | 15 | 3 | 41:25 | 16 | 51 |
| 6 |
|
Estudiantes de Río Cuarto | 30 | 12 | 13 | 5 | 33:26 | 7 | 49 |
| 7 |
|
Chaco For Ever | 31 | 11 | 14 | 6 | 32:22 | 10 | 47 |
| 8 |
|
Estudiantes de Caseros | 30 | 13 | 8 | 9 | 28:25 | 3 | 47 |
| 9 |
|
Almagro | 31 | 13 | 8 | 10 | 29:28 | 1 | 47 |
| 10 |
|
Independiente Rivadavia | 30 | 12 | 10 | 8 | 38:28 | 10 | 46 |
| 11 |
|
Defensores de Belgrano | 30 | 11 | 13 | 6 | 32:23 | 9 | 46 |
| 12 |
|
San Martín de San Juan | 31 | 13 | 6 | 12 | 43:37 | 6 | 45 |
| 13 |
|
Deportivo Riestra | 30 | 10 | 15 | 5 | 29:23 | 6 | 45 |
| 14 |
|
Deportivo Madryn | 30 | 9 | 15 | 6 | 39:31 | 8 | 42 |
| 15 |
|
Deportivo Maipú | 31 | 9 | 15 | 7 | 37:29 | 8 | 42 |
| 16 |
|
Guillermo Brown | 30 | 12 | 5 | 13 | 27:34 | -7 | 41 |
| 17 |
|
Chacarita Juniors | 30 | 10 | 10 | 10 | 43:38 | 5 | 40 |
| 18 |
|
Quilmes | 30 | 10 | 10 | 10 | 37:38 | -1 | 40 |
| 19 |
|
Deportivo Morón | 30 | 8 | 15 | 7 | 24:19 | 5 | 39 |
| 20 |
|
Brown de Adrogué | 30 | 10 | 9 | 11 | 35:33 | 2 | 39 |
| 21 |
|
Mitre de SdE | 30 | 10 | 9 | 11 | 34:34 | 0 | 39 |
| 22 |
|
Almirante Brown | 30 | 9 | 12 | 9 | 33:34 | -1 | 39 |
| 23 |
|
Ferro Carril Oeste | 30 | 10 | 9 | 11 | 25:29 | -4 | 39 |
| 24 |
|
Agropecuario Argentino | 30 | 7 | 14 | 9 | 24:25 | -1 | 35 |
| 25 |
|
Güemes de SdE | 30 | 8 | 11 | 11 | 23:27 | -4 | 35 |
| 26 |
|
Gimnasia de Jujuy | 30 | 9 | 8 | 13 | 31:41 | -10 | 35 |
| 27 |
|
Atlanta | 31 | 7 | 13 | 11 | 24:29 | -5 | 34 |
| 28 |
|
San Telmo | 30 | 7 | 11 | 12 | 28:44 | -16 | 32 |
| 29 |
|
Atlético Rafaela | 30 | 6 | 12 | 12 | 32:36 | -4 | 30 |
| 30 |
|
Temperley | 30 | 5 | 14 | 11 | 27:37 | -10 | 29 |
| 31 |
|
Villa Dálmine | 30 | 5 | 14 | 11 | 32:46 | -14 | 29 |
| 32 |
|
Flandria | 30 | 6 | 10 | 14 | 29:40 | -11 | 28 |
| 33 |
|
Nueva Chicago | 31 | 5 | 13 | 13 | 29:42 | -13 | 28 |
| 34 |
|
Alvarado | 30 | 6 | 10 | 14 | 26:44 | -18 | 28 |
| 35 |
|
Tristan Suárez | 30 | 5 | 11 | 14 | 28:35 | -7 | 26 |
| 36 |
|
Sacachispas | 30 | 3 | 16 | 11 | 19:33 | -14 | 25 |
| 37 |
|
Ramón Santamarina | 30 | 5 | 9 | 16 | 22:46 | -24 | 24 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
