20.04.2022 01:00 Flower City Union - D.C. United 0:3 (0:0)
01:00 FC Cincinnati - Pittsburgh Riverhounds 2:0 (0:0) n.V.
01:00 Miami FC - Inter Miami CF 0:1 (0:0)
01:30 Detroit City FC - Columbus Crew 2:1 (0:1)
02:00 Chicago Fire - Union Omaha 4:5 (0:0, 1:1, 2:2) i.E.
02:00 Birmingham Legion - Tormenta FC 0:2 (0:2)
02:30 Houston Dynamo - Rio Grande Valley FC 2:1 (1:0)
02:30 FC Dallas - FC Tulsa 2:1 (1:1)
04:30 San Jose Earthquakes - Bay Cities FC 5:0 (2:0)
04:30 FC Tucson - California United Strikers 1:2 (1:0)
04:30 Los Angeles Galaxy - San Diego Loyal 1:0 (1:0)
21.04.2022 00:00 Rochester NYFC - FC Motown 4:3 (2:1, 2:2, 2:2) i.E.
00:30 Richmond Kickers - North Carolina Fusion U23 1:0 (0:0, 0:0) n.V.
01:00 Hartford Athletic - New York RB 1:2 (0:2)
01:00 Greenville Triumph SC - Charlotte FC 1:2 (0:1, 1:1) n.V.
01:00 Forward Madison FC - Minnesota United FC 0:2 (0:0)
01:00 Orlando City - Tampa Bay Rowdies 2:1 (0:0)
01:30 Louisville City FC - St. Louis City SC 2 9:8 (0:0, 0:0, 0:0) i.E.
01:30 Atlanta United FC - Chattanooga FC 6:0 (3:0)
02:30 San Antonio FC - Austin FC 2:1 (0:0, 1:1) n.V.
03:30 Real Salt Lake - Northern Colorado Hailstorm 0:1 (0:0)
04:30 Phoenix Rising - New Mexico United 2:1 (1:0)
04:30 Sacramento Republic - Fuego FC 2:1 (1:0)
04:30 Los Angeles FC - Orange County SC 5:1 (3:0)
U.S. Open Cup
U.S. Open Cup