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| 15.04.2022 | 20:00 | De Graafschap | - | TOP Oss | 1:2 (1:1) | |
| 20:00 | FC Dordrecht | - | FC Emmen | 0:1 (0:1) | ||
| 20:00 | FC Eindhoven | - | Jong PSV | 1:3 (0:0) | ||
| 20:00 | MVV | - | SBV Excelsior | 1:1 (1:1) | ||
| 20:00 | Roda JC Kerkrade | - | Helmond Sport | 5:3 (3:1) | ||
| 20:00 | VVV-Venlo | - | Telstar | 3:2 (1:0) | ||
| 20:00 | AZ Alkmaar (J) | - | ADO Den Haag | 0:1 (0:0) | ||
| 16.04.2022 | 16:30 | FC Volendam | - | Jong Ajax | 3:1 (1:1) | |
| 21:00 | Almere City FC | - | NAC Breda | 1:2 (0:0) | ||
| 18.04.2022 | 20:00 | FC Utrecht (J) | - | FC Den Bosch | 0:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Emmen | 35 | 24 | 5 | 6 | 59:23 | 36 | 77 |
| 2 |
|
FC Volendam | 35 | 20 | 11 | 4 | 75:47 | 28 | 71 |
| 3 |
|
FC Eindhoven | 35 | 19 | 7 | 9 | 65:41 | 24 | 64 |
| 4 |
|
Roda JC Kerkrade | 35 | 17 | 12 | 6 | 73:44 | 29 | 63 |
| 5 |
|
SBV Excelsior | 35 | 19 | 6 | 10 | 75:50 | 25 | 63 |
| 6 |
|
ADO Den Haag | 35 | 21 | 6 | 8 | 74:49 | 25 | 63 |
| 7 |
|
Jong Ajax | 35 | 17 | 8 | 10 | 75:60 | 15 | 59 |
| 8 |
|
NAC Breda | 35 | 15 | 10 | 10 | 54:41 | 13 | 55 |
| 9 |
|
De Graafschap | 35 | 14 | 9 | 12 | 46:41 | 5 | 51 |
| 10 |
|
VVV-Venlo | 35 | 13 | 5 | 17 | 44:54 | -10 | 44 |
| 11 |
|
FC Den Bosch | 35 | 13 | 4 | 18 | 39:58 | -19 | 43 |
| 12 |
|
Jong PSV | 35 | 11 | 8 | 16 | 57:59 | -2 | 41 |
| 13 |
|
TOP Oss | 35 | 11 | 8 | 16 | 46:55 | -9 | 41 |
| 14 |
|
Almere City FC | 35 | 10 | 8 | 17 | 54:63 | -9 | 38 |
| 15 |
|
AZ Alkmaar (J) | 35 | 11 | 5 | 19 | 33:46 | -13 | 38 |
| 16 |
|
Telstar | 35 | 8 | 11 | 16 | 43:66 | -23 | 35 |
| 17 |
|
FC Utrecht (J) | 35 | 10 | 4 | 21 | 37:62 | -25 | 34 |
| 18 |
|
MVV | 35 | 10 | 3 | 22 | 39:73 | -34 | 33 |
| 19 |
|
FC Dordrecht | 35 | 8 | 8 | 19 | 47:73 | -26 | 32 |
| 20 |
|
Helmond Sport | 35 | 7 | 6 | 22 | 37:67 | -30 | 24 |
| Aufstieg | |
| Playoffs | |
| Playoffs |
|
# ADO Den Haag: -6 P. # Helmond Sport: -3 P. |
