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| 14.10.2005 | 20:00 | FC Omniworld | - | SC Cambuur | 2:0 (0:0) | |
| 20:00 | FC Dordrecht | - | FC Eindhoven | 1:1 (1:1) | ||
| 20:00 | FC Zwolle | - | VVV-Venlo | 1:1 (0:1) | ||
| 20:00 | Helmond Sport | - | FC Emmen | 2:1 (1:1) | ||
| 20:00 | MVV | - | Go Ahead Eagles | 1:0 (0:0) | ||
| 20:00 | TOP Oss | - | Fortuna Sittard | 3:1 (1:0) | ||
| 20:00 | BV Veendam | - | AGOVV | 1:0 (1:0) | ||
| 20:00 | De Graafschap | - | SBV Excelsior | 1:1 (0:0) | ||
| 16.10.2005 | 14:30 | FC Volendam | - | FC Den Bosch | 4:2 (2:0) | |
| 14:30 | HFC Haarlem | - | Stormvogels Telstar | 2:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VVV-Venlo | 13 | 9 | 3 | 1 | 23:6 | 17 | 30 |
| 2 |
|
FC Volendam | 13 | 9 | 3 | 1 | 24:8 | 16 | 30 |
| 3 |
|
SBV Excelsior | 13 | 8 | 3 | 2 | 23:8 | 15 | 27 |
| 4 |
|
FC Den Bosch | 13 | 8 | 2 | 3 | 28:18 | 10 | 26 |
| 5 |
|
Helmond Sport | 13 | 8 | 2 | 3 | 23:13 | 10 | 26 |
| 6 |
|
FC Zwolle | 13 | 7 | 4 | 2 | 21:13 | 8 | 25 |
| 7 |
|
FC Emmen | 13 | 7 | 2 | 4 | 25:18 | 7 | 23 |
| 8 |
|
MVV | 13 | 5 | 4 | 4 | 19:16 | 3 | 19 |
| 9 |
|
AGOVV | 13 | 5 | 2 | 6 | 21:24 | -3 | 17 |
| 10 |
|
BV Veendam | 13 | 4 | 4 | 5 | 14:16 | -2 | 16 |
| 11 |
|
FC Dordrecht | 13 | 4 | 4 | 5 | 13:16 | -3 | 16 |
| 12 |
|
De Graafschap | 13 | 4 | 4 | 5 | 12:16 | -4 | 16 |
| 13 |
|
Go Ahead Eagles | 13 | 3 | 5 | 5 | 20:25 | -5 | 14 |
| 14 |
|
FC Eindhoven | 13 | 3 | 3 | 7 | 22:25 | -3 | 12 |
| 15 |
|
Stormvogels Telstar | 13 | 1 | 7 | 5 | 11:18 | -7 | 10 |
| 16 |
|
FC Omniworld | 13 | 3 | 1 | 9 | 16:28 | -12 | 10 |
| 17 |
|
TOP Oss | 13 | 2 | 4 | 7 | 13:25 | -12 | 10 |
| 18 |
|
SC Cambuur | 13 | 2 | 6 | 5 | 15:18 | -3 | 9 |
| 19 |
|
HFC Haarlem | 13 | 2 | 3 | 8 | 11:28 | -17 | 9 |
| 20 |
|
Fortuna Sittard | 13 | 1 | 4 | 8 | 13:28 | -15 | 7 |
| Aufstieg |
|
# Cambuur-Leeuwarden bekam 3 Punkte abgezogen. |
