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| H | Club Irapuato | - | Club León | 0:1 | ||
| R | Club León | - | Club Irapuato | 2:0 | ||
| H: 23.11.2011 22:00 | R: 27.11.2011 04:00 | Sieger: Club León | ||||
| H | Estudiantes de Altamira | - | Correcaminos UAT | 2:1 | ||
| R | Correcaminos UAT | - | Estudiantes de Altamira | 1:0 | ||
| H: 25.11.2011 01:00 | R: 28.11.2011 01:00 | Sieger: Correcaminos UAT | ||||
| H | Club Necaxa | - | Neza FC | 0:1 | ||
| R | Neza FC | - | Club Necaxa | 2:2 | ||
| H: 25.11.2011 03:00 | R: 27.11.2011 19:00 | Sieger: Neza FC | ||||
